DREAM is a Dialogue for Reverse Engineering Assessments and Methods. The main objective is to catalyze the interaction between experiment and theory in the area of cellular network inference and quantitative model building in systems biology.
"The DREAM Project has teamed up with Sage Bionetworks and
announced four open challenges in computational biology that tackle
issues relevant to drug discovery and development, including prediction
of drug responses..."
Two Science Translational Medicine Reports: DREAM and Sage Bionetworks Tap into the Wisdom of the Crowd to Fight the Challenge of Breast Cancer Prognosis and Treatment
An interesting discussion in the blog: "21st Century Scientist, Thoughts on modern scientific research", on the pros and cons of sharing code in collaborative-competitions such as the Sage Bionetworks-DREAM challenge.